Route 66!

By Benjamin Musrie, Medical Researcher. Sydney, Australia.

Illustration by Jenny Liu

The cells cytoskeleton is a dynamic network composed of three main components — microfilaments, intermediate filaments and microtubules. The cytoskeleton gives the cell its shape and provides mechanical support that enables the cell to carry out functions such as division and movement. Microtubules are microscopic tubes made up of alpha and beta tubulin heterodimers which undergo continuous polymerisation and depolymerisation. They are involved in cell division, organisation of intracellular structure and intracellular transport. Axonal transport is one of the most critical functions of microtubules and is crucial for neuronal homeostasis. …


The absolute must-do for gene expression studies!

By Benjamin Musrie, Medical Researcher. Sydney, Australia.

A transcriptional landscape with each number varying in image and colour to depict the change in quality of RNA
A transcriptional landscape with each number varying in image and colour to depict the change in quality of RNA
Illustration by Jenny Liu

Focussing on the genomics side of ALS means crunching a lot of genomic data. Gene expression analysis always includes RNA samples. Determining the quality of RNA samples is essential to ensure that the resulting gene expression analysis is both accurate and precise. As a result, assessment of RNA integrity number (RIN) has become standard practice prior to any RNA sequencing study, as it was shown to be robust and reproducible when compared to other RNA integrity calculation algorithms such as the 28S:18S ribosomal subunit ratio (Imbeaud et al., 2005).

RNA degradation — which…


The main mantra is — higher the diversity, better the health!

By Benjamin Musrie, Medical Researcher. Sydney, Australia.

The brain as a puzzle and a piece of the puzzle is missing and the missing puzzle piece is in the gut representing that the microbiome is a piece of the puzzle of neurodegeneration
The brain as a puzzle and a piece of the puzzle is missing and the missing puzzle piece is in the gut representing that the microbiome is a piece of the puzzle of neurodegeneration
Illustration by Jenny Liu

A great portion of our work at GenieUs has revolved around the human microbiome and its role in neurodegeneration. It’s interesting because the link isn’t a particularly obvious one and most people wouldn’t think it plays such a critical part in the development of neurodegenerative diseases. It’s not just the type of bacteria that colonise us, but also the intricate interactions and signalling they relay within the body. …


Should we be focusing on Microglia as a therapeutic target for ALS?

By Benjamin Musrie, Medical Researcher. Sydney, Australia.

An illustrative impression of a microglia cell cleaning cell waste
An illustrative impression of a microglia cell cleaning cell waste
Illustration by Jenny Liu

Over the course of 2020, one of our research labs main focuses was on microglia and their role in ALS disease and progression. We believe their role is central in the initiation and progression of ALS and needs to be more widely explored. At the current moment, we have a paper in the pipeline authored by one of our lead bioinformaticians, in which he will specifically delve into the role of microglia in ALS formation and progression. In our very first blog, we will outline microglia function, its proposed role in ALS and…

GenieUs Genomics

We are a restless science and technology company focused on solving the mystery of neurodegenerative diseases. Visit us at https://genieus.co/

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